Genome Canada has launched a new funding opportunity for generation of population-level genomic data, which will be the first pillar of its soon-to-be announced large-scale precision health initiative. The goal of Genome Canada’s planned investment in the first pillar of the initiative is to sequence the genomes of at least 100,000 Canadians, reflecting Canada’s unique and diverse population. This will provide the rich dataset needed to advance research, drive innovation and improve health-care outcomes for all Canadians.